Integrative Toxicoproteomics Implicates Impaired Mitochondrial Glutathione Import as an Off-Target Effect of Troglitazone

[Image: see text] Troglitazone, a first-generation thiazolidinedione of antihyperglycaemic properties, was withdrawn from the market due to unacceptable idiosyncratic hepatotoxicity. Despite intensive research, the underlying mechanism of troglitazone-induced liver toxicity remains unknown. Here we...

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Detalhes bibliográficos
Main Authors: Lee, Yie Hou, Goh, Wilson Wen Bin, Ng, Choon Keow, Raida, Manfred, Wong, Limsoon, Lin, Qingsong, Boelsterli, Urs A., Chung, Maxey C. M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3805328/
https://ncbi.nlm.nih.gov/pubmed/23659346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/pr400219s
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