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The role of membrane cholesterol in determining bile acid cytotoxicity and cytoprotection of ursodeoxycholic acid
In cholestatic liver diseases, the ability of hydrophobic bile acids to damage membranes of hepatocytes/ductal cells contributes to their cytotoxicity. However, ursodeoxycholic acid (UDC), a hydrophilic bile acid, is used to treat cholestasis because it protects membranes. It has been well establish...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3805258/ https://ncbi.nlm.nih.gov/pubmed/19150330 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2008.12.008 |
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