Aberrant ZNF423 impedes B cell differentiation and is linked to adverse outcome of ETV6-RUNX1 negative B precursor acute lymphoblastic leukemia

Differentiation arrest is a hallmark of acute leukemia. Genomic alterations in B cell differentiation factors such as PAX5, IKZF1, and EBF-1 have been identified in more than half of all cases of childhood B precursor acute lymphoblastic leukemia (ALL). Here, we describe a perturbed epigenetic and t...

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Main Authors: Harder, Lena, Eschenburg, Georg, Zech, Antonia, Kriebitzsch, Neele, Otto, Benjamin, Streichert, Thomas, Behlich, Anna-Sophie, Dierck, Kevin, Klingler, Bine, Hansen, Arne, Stanulla, Martin, Zimmermann, Martin, Kremmer, Elisabeth, Stocking, Carol, Horstmann, Martin A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3804944/
https://ncbi.nlm.nih.gov/pubmed/24081948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20130497
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