Neutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow

Blood neutrophil homeostasis is essential for successful host defense against invading pathogens. Circulating neutrophil counts are positively regulated by CXCR2 signaling and negatively regulated by the CXCR4–CXCL12 axis. In particular, G-CSF, a known CXCR2 signaler, and plerixafor, a CXCR4 antagon...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Devi, Sapna, Wang, Yilin, Chew, Weng Keong, Lima, Ronald, A-González, Noelia, Mattar, Citra N.Z., Chong, Shu Zhen, Schlitzer, Andreas, Bakocevic, Nadja, Chew, Samantha, Keeble, Jo L., Goh, Chi Ching, Li, Jackson L.Y., Evrard, Maximilien, Malleret, Benoit, Larbi, Anis, Renia, Laurent, Haniffa, Muzlifah, Tan, Suet Mien, Chan, Jerry K.Y., Balabanian, Karl, Nagasawa, Takashi, Bachelerie, Françoise, Hidalgo, Andrés, Ginhoux, Florent, Kubes, Paul, Ng, Lai Guan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Rockefeller University Press 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3804935/
https://ncbi.nlm.nih.gov/pubmed/24081949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20130056
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