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GKAP/SAPAP orchestrates activity-dependent postsynaptic protein remodeling and homeostatic scaling
How does chronic activity modulation lead to global remodeling of proteins at synapses and synaptic scaling? Here we report a role of guanylate-kinase-associated-protein (GKAP; also known as SAPAP), a scaffolding molecule linking NMDA receptor-PSD-95 to Shank-Homer complexes, in these processes. Ove...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3804128/ https://ncbi.nlm.nih.gov/pubmed/23143515 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3259 |
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