Prolonged Alendronate Treatment Prevents The Decline In Serum TGF-β1 Levels And Reduces Cortical Bone Strength In Long-Term Estrogen Deficiency Rat Model

INTRODUCTION: While the anti-resorptive effects of the bisphosphonates (BPs) are well documented, many questions remain about their mechanisms of action, particularly following long-term use. This study evaluated the effects of alendronate (Ale) treatment on TGF-β1 signaling in mesenchymal stem cell...

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Hauptverfasser: Jia, Junjing, Yao, Wei, Amugongo, Sarah, Shahnazari, Mohammad, Dai, Weiwei, Lay, Yuan E., Olvera, Diana, Zimmermann, Elizabeth A., Ritchie, Robert O., Li, Chin-Shang, Alliston, Tamara, Lane, Nancy E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3804116/
https://ncbi.nlm.nih.gov/pubmed/23088940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2012.10.017
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