Anthrax toxin-mediated delivery of a cytotoxic T-cell epitope in vivo.
The protective antigen (PA) component of anthrax toxin mediates entry of the toxin's lethal factor (LF) and edema factor into the cytosolic compartment of mammalian cells. The amino-terminal domain of LF (LFn; 255 amino acids) binds LF to PA, and when fused to heterologous proteins, the LFn domain d...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
1996
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38026/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8901616/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.22.12531 |
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