Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells

APE1/Ref-1 protects cells from oxidative stress by acting as a central enzyme in base excision repair pathways of DNA lesions and through its independent activity as a redox transcriptional co-activator. Dysregulation of this protein has been associated to cancer development. At present, contrasting...

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Hauptverfasser: Vascotto, Carlo, Cesaratto, Laura, Zeef, Leo A.H., Deganuto, Marta, D’Ambrosio, Chiara, Scaloni, Andrea, Romanello, Milena, Damante, Giuseppe, Taglialatela, Giulio, Delneri, Daniela, Kelley, Mark R., Mitra, Sankar, Quadrifoglio, Franco, Tell, Gianluca
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3802553/
https://ncbi.nlm.nih.gov/pubmed/19180539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pmic.200800638
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