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The Role of HIV-1 Vpr in Promoting the Infection of non-dividing Cells and in Cell Cycle Arrest
PURPOSE: The search for the role(s) that HIV-1 Vpr and its HIV2/SIV paralogs Vpr and Vpx play in viral infection and pathogenesis showed that all three engage CRL4 ubiquitin ligase complexes. This association triggers ubiquitination and degradation of cellular substrates. The identity of the ubiquit...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3802534/ https://ncbi.nlm.nih.gov/pubmed/22274659 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/COH.0b013e32835049e0 |
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