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TGF-β Cytokine Signaling Promotes CD8(+) T Cell Development and Low-affinity CD4(+) T Cell Homeostasis by Regulation of Interleukin-7 Receptor-α Expression
Interleukin 7 receptor α-chain (IL-7Rα) is induced upon T cell positive selection, and controls thymic CD8-lineage specification and peripheral naïve T cell homeostasis. How IL-7Rα expression is regulated in developing thymocytes is unclear. Here we showed that transforming growth factor-β (TGF-β) s...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3801187/ https://ncbi.nlm.nih.gov/pubmed/23932572 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2013.07.016 |
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