Identification of apolipoprotein D as a cardioprotective gene using a mouse model of lethal atherosclerotic coronary artery disease

Mice with homozygous null mutations in the HDL receptor (scavenger receptor class B, type I, or SR-BI) and apolipoprotein E (apoE) genes [SR-BI/apoE double KO (SR-BI(−/−)/apoE(−/−) or dKO) mice] spontaneously develop occlusive, atherosclerotic coronary artery disease (CAD) and die prematurely (50% m...

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Autores principales: Tsukamoto, Kosuke, Mani, D. R., Shi, Jianru, Zhang, Songwen, Haagensen, Darrow E., Otsuka, Fumiyuki, Guan, Jian, Smith, Jonathan D., Weng, Wei, Liao, Ronglih, Kolodgie, Frank D., Virmani, Renu, Krieger, Monty
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2013
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3801016/
https://ncbi.nlm.nih.gov/pubmed/24082102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1315986110
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