Double minute chromosomes in glioblastoma multiforme are revealed by precise reconstruction of oncogenic amplicons

DNA sequencing offers a powerful tool in oncology based on the precise definition of structural rearrangements, copy number in tumor genomes. Here we describe the development of methods to compute copy number and detect structural variants with data synthesis to locally reconstruct highly rearranged...

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Main Authors: Sanborn, J. Zachary, Salama, Sofie R., Grifford, Mia, Brennan, Cameron W., Mikkelsen, Tom, Jhanwar, Suresh, Katzman, Sol, Chin, Lynda, Haussler, David
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3800429/
https://ncbi.nlm.nih.gov/pubmed/23940299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-0186
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