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RIP2 activity in inflammatory disease and implications for novel therapeutics

The role of NOD2 and RIP2 in inflammatory disease has been paradoxical. Whereas loss-of-function NOD2 polymorphisms cause CD, a granulomatous disease of the gastrointestinal tract, gain-of-function mutations cause EOS—a granulomatous disease primarily affecting the skin, joints, and eyes. Thus, gain...

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Sonraí Bibleagrafaíochta
Main Authors: Jun, Janice C., Cominelli, Fabio, Abbott, Derek W.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Society for Leukocyte Biology 2013
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3800061/
https://ncbi.nlm.nih.gov/pubmed/23794710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0213109
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