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Resistance Emerges to Second Generation Anti-Androgens in Prostate Cancer

The appearance of a mutant androgen receptor, F876L-AR, in prostate cancer cells chronically exposed to enzalutamide or ARN-509 promotes a switch from antagonist to agonist receptor function, undermining the potential long term effectiveness of these second generation anti-androgen drugs.

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Detalhes bibliográficos
Main Authors: Nelson, William G., Yegnasubramanian, Srinivasan
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3800038/
https://ncbi.nlm.nih.gov/pubmed/24019330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-0405
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