5-Aminolevulinic Acid Induced Fluorescence Is a Powerful Intraoperative Marker for Precise Histopathological Grading of Gliomas with Non-Significant Contrast-Enhancement

BACKGROUND: Intraoperative identification of anaplastic foci in diffusely infiltrating gliomas (DIG) with non-significant contrast-enhancement on MRI is indispensible to avoid histopathological undergrading and subsequent treatment failure. Recently, we found that 5-aminolevulinic acid (5-ALA) induc...

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Main Authors: Widhalm, Georg, Kiesel, Barbara, Woehrer, Adelheid, Traub-Weidinger, Tatjana, Preusser, Matthias, Marosi, Christine, Prayer, Daniela, Hainfellner, Johannes A., Knosp, Engelbert, Wolfsberger, Stefan
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3800004/
https://ncbi.nlm.nih.gov/pubmed/24204718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0076988
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