Depletion of the transcriptional coactivators megakaryoblastic leukaemia 1 and 2 abolishes hepatocellular carcinoma xenograft growth by inducing oncogene-induced senescence

Megakaryoblastic leukaemia 1 and 2 (MKL1/2) are coactivators of the transcription factor serum response factor (SRF). Here, we provide evidence that depletion of MKL1 and 2 abolishes hepatocellular carcinoma (HCC) xenograft growth. Loss of the tumour suppressor deleted in liver cancer 1 (DLC1) and t...

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Autori principali: Hampl, Veronika, Martin, Claudia, Aigner, Achim, Hoebel, Sabrina, Singer, Stephan, Frank, Natalie, Sarikas, Antonio, Ebert, Oliver, Prywes, Ron, Gudermann, Thomas, Muehlich, Susanne
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Publishing Ltd 2013
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799492/
https://ncbi.nlm.nih.gov/pubmed/23853104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201202406
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