NF-κB inhibitor targeted to activated endothelium demonstrates a critical role of endothelial NF-κB in immune-mediated diseases

Activation of the nuclear transcription factor κB (NF-κB) regulates the expression of inflammatory genes crucially involved in the pathogenesis of inflammatory diseases. NF-κB governs the expression of adhesion molecules that play a pivotal role in leukocyte–endothelium interactions. We uncovered th...

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Hauptverfasser: Sehnert, Bettina, Burkhardt, Harald, Wessels, Johannes T., Schröder, Agnes, May, Michael J., Vestweber, Dietmar, Zwerina, Jochen, Warnatz, Klaus, Nimmerjahn, Falk, Schett, Georg, Dübel, Stefan, Voll, Reinhard Edmund
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2013
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799326/
https://ncbi.nlm.nih.gov/pubmed/24062461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218219110
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