The Effect of Molecular Weight, PK, and Valency on Tumor Biodistribution and Efficacy of Antibody-Based Drugs

Poor drug delivery and penetration of antibody-mediated therapies pose significant obstacles to effective treatment of solid tumors. This study explored the role of pharmacokinetics, valency, and molecular weight in maximizing drug delivery. Biodistribution of a fibroblast growth factor receptor 4 (...

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Detalhes bibliográficos
Main Authors: Muchekehu, Ruth, Liu, Dingguo, Horn, Mark, Campbell, Lioudmila, Del Rosario, Joselyn, Bacica, Michael, Moskowitz, Haim, Osothprarop, Trina, Dirksen, Anouk, Doppalapudi, Venkata, Kaspar, Allan, Pirie-Shepherd, Steven R, Coronella, Julia
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press Inc. 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799199/
https://ncbi.nlm.nih.gov/pubmed/24151537
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