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MicroRNA-34a Enhances T Cell Activation by Targeting Diacylglycerol Kinase ζ
The engagement of the T cell receptor (TCR) induces the generation of diacylglycerol (DAG), an important second messenger activating both the Ras/Erk and PKCθ/NFκB pathways. DAG kinases (DGKs) participate in the metabolism of DAG by converting it to phosphatidic acid. DGKζ has been demonstrated to b...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3798301/ https://ncbi.nlm.nih.gov/pubmed/24147106 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0077983 |
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