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Local delivery of controlled-release simvastatin/PLGA/HAp microspheres enhances bone repair

Statins are used clinically for reduction of cholesterol synthesis to prevent cardiovascular disease. Previous in vitro and in vivo studies have shown that statins stimulate bone formation. However, orally administered statins may be degraded during first-pass metabolism in the liver. This study aim...

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Bibliografske podrobnosti
Main Authors: Tai, I-Chun, Fu, Yin-Chih, Wang, Chih-Kuang, Chang, Je-Ken, Ho, Mei-Ling
Format: Artigo
Jezik:Inglês
Izdano: Dove Medical Press 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798145/
https://ncbi.nlm.nih.gov/pubmed/24143094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S48694
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