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Local delivery of controlled-release simvastatin/PLGA/HAp microspheres enhances bone repair
Statins are used clinically for reduction of cholesterol synthesis to prevent cardiovascular disease. Previous in vitro and in vivo studies have shown that statins stimulate bone formation. However, orally administered statins may be degraded during first-pass metabolism in the liver. This study aim...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Dove Medical Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3798145/ https://ncbi.nlm.nih.gov/pubmed/24143094 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S48694 |
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