The Tumor Suppressor Gene, RASSF1A, Is Essential for Protection against Inflammation -Induced Injury

Ras association domain family protein 1A (RASSF1A) is a tumor suppressor gene silenced in cancer. Here we report that RASSF1A is a novel regulator of intestinal inflammation as Rassf1a(+/−), Rassf1a(−/−) and an intestinal epithelial cell specific knockout mouse (Rassf1a( IEC-KO)) rapidly became sick...

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Main Authors: Gordon, Marilyn, El-Kalla, Mohamed, Zhao, Yuewen, Fiteih, Yahya, Law, Jennifer, Volodko, Natalia, Mohamed, Anwar, El-Kadi, Ayman O. S., Liu, Lei, Odenbach, Jeff, Thiesen, Aducio, Onyskiw, Christina, Ghazaleh, Haya Abu, Park, Jikyoung, Lee, Sean Bong, Yu, Victor C., Fernandez-Patron, Carlos, Alexander, R. Todd, Wine, Eytan, Baksh, Shairaz
格式: Artigo
語言:Inglês
出版: Public Library of Science 2013
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3797720/
https://ncbi.nlm.nih.gov/pubmed/24146755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0075483
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