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Targeting hedgehog signaling in cancer: research and clinical developments

Since its first description in Drosophila by Drs Nusslein-Volhard and Wieschaus in 1980, hedgehog (Hh) signaling has been implicated in regulation of cell differentiation, proliferation, tissue polarity, stem cell maintenance, and carcinogenesis. The first link of Hh signaling to cancer was establis...

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Detalhes bibliográficos
Main Authors: Xie, Jingwu, Bartels, Christopher M, Barton, Scott W, Gu, Dongsheng
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3797650/
https://ncbi.nlm.nih.gov/pubmed/24143114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S34678
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