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A novel application of maleimide for advanced drug delivery: in vitro and in vivo evaluation of maleimide-modified pH-sensitive liposomes

Maleimide is a stable and easy-to-handle moiety that rapidly and covalently conjugates thiol groups of cysteine residues in proteins or peptides. Herein, we use maleimide to modify the surface of liposomes in order to obtain an advanced drug delivery system. Employing a small amount (0.3 mol%) of ma...

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Detalles Bibliográficos
Main Authors: Li, Tianshu, Takeoka, Shinji
Formato: Artigo
Idioma:Inglês
Publicado: Dove Medical Press 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3797616/
https://ncbi.nlm.nih.gov/pubmed/24143089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S47749
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