Sphingosine-1-phosphate receptor-3 signaling up-regulates epidermal growth factor receptor and enhances epidermal growth factor receptor-mediated carcinogenic activities in cultured lung adenocarcinoma cells

Sphingosine-1-phosphate (S1P) regulates a wide array of biological functions. However, the role of S1P signaling in tumorigenesis remains to be elucidated. In this study, we show that S1P receptor subtype 3 (S1P(3)) is markedly up-regulated in a subset of lung adenocarcinoma cells compared to normal...

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Detalhes bibliográficos
Main Authors: HSU, ANDREW, ZHANG, WENLIANG, LEE, JEN-FU, AN, JIN, EKAMBARAM, PRASANNA, LIU, JINGJING, HONN, KENNETH V., KLINGE, CAROLYN M., LEE, MENQ-JER
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3797598/
https://ncbi.nlm.nih.gov/pubmed/22344462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2012.1379
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