Targeting phosphodiesterase 3B enhances cisplatin sensitivity in human cancer cells

We previously reported that human squamous cell carcinoma (SCC) cell lines refractory to cis-diaminedichloro-platinum II (cisplatin [CDDP]) had significant upregulation of the phosphodiesterase 3B gene (PDE3B), suggesting that inhibiting PDE3B suppresses CDDP resistance. shRNA-mediated PDE3B depleti...

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Detalhes bibliográficos
Main Authors: Uzawa, Katsuhiro, Kasamatsu, Atsushi, Baba, Takao, Usukura, Katsuya, Saito, Yasuhiro, Sakuma, Kentaro, Iyoda, Manabu, Sakamoto, Yosuke, Ogawara, Katsunori, Shiiba, Masashi, Tanzawa, Hideki
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3797561/
https://ncbi.nlm.nih.gov/pubmed/24133626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.56
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