IL-27 Enhances the Expression of TRAIL and TLR3 in Human Melanomas and Inhibits Their Tumor Growth in Cooperation with a TLR3 Agonist Poly(I:C) Partly in a TRAIL-Dependent Manner

Interleukin (IL)-27 is a member of the IL-6/IL-12 cytokine family and possesses potent antitumor activity, which is mediated by multiple mechanisms. Toll-like receptor (TLR)3 is the critical sensor of the innate immune system that serves to identify viral double-stranded RNA. TLR3 is frequently expr...

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Detalhes bibliográficos
Main Authors: Chiba, Yukino, Mizoguchi, Izuru, Mitobe, Kana, Higuchi, Kaname, Nagai, Hiroshi, Nishigori, Chikako, Mizuguchi, Junichiro, Yoshimoto, Takayuki
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3796519/
https://ncbi.nlm.nih.gov/pubmed/24155891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0076159
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