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Direct Measurements of Human Colon Crypt Stem Cell Niche Genetic Fidelity: The Role of Chance in Non-Darwinian Mutation Selection

Perfect human stem cell genetic fidelity would prevent aging and cancer. However, perfection would be difficult to achieve, and aging is universal and cancers common. A hypothesis is that because mutations are inevitable over a human lifetime, downstream mechanisms have evolved to manage the deleter...

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Detalhes bibliográficos
Main Authors: Kang, Haeyoun, Shibata, Darryl
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3796283/
https://ncbi.nlm.nih.gov/pubmed/24133655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2013.00264
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