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"Aggrecanase" activity is implicated in tumour necrosis factor alpha mediated cartilage aggrecan breakdown but is not detected by an in vitro assay.

AIMS: To develop an in vitro assay for the putative glutamyl endopeptidase, "aggrecanase", which is thought to degrade cartilage aggrecan, and to examine the role of the enzyme in tumour necrosis factor stimulated aggrecan cleavage. METHODS: Aggrecan fragments released by bovine nasal cartilage expl...

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Udgivet i:Mol Pathol
Principais autores: Buttle, D. J., Fowles, A., Ilic, M. Z., Handley, C. J.
Format: Artigo
Sprog:Inglês
Udgivet: BMJ Publishing Group 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC379611/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9292151/
https://ncbi.nlm.nih.govhttps://doi.org/10.1136/mp.50.3.153
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