ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: A comprehensive analysis from the Ovarian Cancer Association Consortium and The Cancer Genome Atlas

OBJECTIVE: ABCB1 encodes the multi-drug efflux pump P-glycoprotein (P-gp) and has been implicated in multi-drug resistance. We comprehensively evaluated this gene and flanking regions for an association with clinical outcome in epithelial ovarian cancer (EOC). METHODS: The best candidates from fine-...

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Autors principals: Johnatty, Sharon E., Beesley, Jonathan, Gao, Bo, Chen, Xiaoqing, Lu, Yi, Law, Matthew H., Henderson, Michelle J., Russell, Amanda J., Hedditch, Ellen L., Emmanuel, Catherine, Fereday, Sian, Webb, Penelope M., Goode, Ellen L., Vierkant, Robert A., Fridley, Brooke L., Cunningham, Julie M, Fasching, Peter A., Beckmann, Matthias W., Ekici, Arif B., Hogdall, Estrid, Kjaer, Susanne K., Jensen, Allan, Hogdall, Claus, Brown, Robert, Paul, Jim, Lambrechts, Sandrina, Despierre, Evelyn, Vergote, Ignace, Lester, Jenny, Karlan, Beth Y., Heitz, Florian, du Bois, Andreas, Harter, Philipp, Schwaab, Ira, Bean, Yukie, Pejovic, Tanja, Levine, Douglas A., Goodman, Marc T., Camey, Michael E., Thompson, Pamela J., Lurie, Galina, Shildkraut, Joellen, Berchuck, Andrew, Terry, Kathryn L., Cramer, Daniel W., Norris, Murray D., Haber, Michelle, MacGregor, Stuart, deFazio, Anna, Chenevix-Trench, Georgia
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795832/
https://ncbi.nlm.nih.gov/pubmed/23917080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2013.07.107
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