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The roles of IRF-3 and IRF-7 in innate antiviral immunity against dengue virus
We investigated the roles of IRF-3 and IRF-7 in innate antiviral immunity against dengue virus (DENV). Double-deficient Irf-3(−/−)7(−/−) mice infected with the DENV2 strain S221 possessed 1,000–150,000 fold higher levels of viral RNA than wild-type and single-deficient mice 24 hours after infection;...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3795795/ https://ncbi.nlm.nih.gov/pubmed/24043884 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1300799 |
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