Hydrogen-bond network and pH sensitivity in human transthyretin

Transthyretin (TTR) is a tetrameric protein. TTR misfolding and aggregation are associated with human amyloid diseases. Dissociation of the TTR tetramer is believed to be the rate-limiting step in the amyloid fibril formation cascade. Low pH is known to promote dissociation into monomer and the form...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Yokoyama, Takeshi, Mizuguchi, Mineyuki, Nabeshima, Yuko, Kusaka, Katsuhiro, Yamada, Taro, Hosoya, Takaaki, Ohhara, Takashi, Kurihara, Kazuo, Tanaka, Ichiro, Niimura, Nobuo
Médium: Artigo
Jazyk:Inglês
Vydáno: International Union of Crystallography 2013
Témata:
Diffraction Structural Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795539/
https://ncbi.nlm.nih.gov/pubmed/24121323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S090904951302075X
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky