Hydrogen-bond network and pH sensitivity in human transthyretin

Transthyretin (TTR) is a tetrameric protein. TTR misfolding and aggregation are associated with human amyloid diseases. Dissociation of the TTR tetramer is believed to be the rate-limiting step in the amyloid fibril formation cascade. Low pH is known to promote dissociation into monomer and the form...

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Detalhes bibliográficos
Main Authors: Yokoyama, Takeshi, Mizuguchi, Mineyuki, Nabeshima, Yuko, Kusaka, Katsuhiro, Yamada, Taro, Hosoya, Takaaki, Ohhara, Takashi, Kurihara, Kazuo, Tanaka, Ichiro, Niimura, Nobuo
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2013
Assuntos:
Diffraction Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795539/
https://ncbi.nlm.nih.gov/pubmed/24121323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S090904951302075X
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