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Rad5 Template Switch Pathway of DNA Damage Tolerance Determines Synergism between Cisplatin and NSC109268 in Saccharomyces cerevisiae

The success of cisplatin (CP) based therapy is often hindered by acquisition of CP resistance. We isolated NSC109268 as a compound altering cellular sensitivity to DNA damaging agents. Previous investigation revealed an enhancement of CP sensitivity by NSC109268 in wild-type Saccharomyces cerevisiae...

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Bibliografski detalji
Glavni autori: Jain, Dilip, Siede, Wolfram
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795065/
https://ncbi.nlm.nih.gov/pubmed/24130896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0077666
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