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Concordance of gene expression in human protein complexes reveals tissue specificity and pathology
Disease-causing variants in human genes usually lead to phenotypes specific to only a few tissues. Here, we present a method for predicting tissue specificity based on quantitative deregulation of protein complexes. The underlying assumption is that the degree of coordinated expression among protein...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3794609/ https://ncbi.nlm.nih.gov/pubmed/23921638 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt661 |
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