The ubiquitin specific protease USP34 promotes ubiquitin signaling at DNA double-strand breaks

Ubiquitylation plays key roles in DNA damage signal transduction. The current model envisions that lysine63-linked ubiquitin chains, via the concerted action of E3 ubiquitin ligases RNF8-RNF168, are built at DNA double-strand breaks (DSBs) to effectively assemble DNA damage-repair factors for proper...

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Detalhes bibliográficos
Main Authors: Sy, Shirley M. H., Jiang, Jun, O, Wai Sum, Deng, Yiqun, Huen, Michael S. Y.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3794584/
https://ncbi.nlm.nih.gov/pubmed/23863847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt622
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