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Long-lasting response to crizotinib in brain metastases due to EML4-ALK-rearranged non-small-cell lung cancer
Anaplastic lymphoma kinase (ALK) rearranged non-small-cell lung cancer (NSCLC) is highly responsive to crizotinib, an oral ATP-competitive selective inhibitor of ALK. However, crizotinib exhibits extremely poor blood–brain barrier penetration; therefore, it is considered to play a limited role in th...
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| Główni autorzy: | , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
BMJ Publishing Group
2013
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3794239/ https://ncbi.nlm.nih.gov/pubmed/24022905 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bcr-2013-200867 |
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