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Long-lasting response to crizotinib in brain metastases due to EML4-ALK-rearranged non-small-cell lung cancer

Anaplastic lymphoma kinase (ALK) rearranged non-small-cell lung cancer (NSCLC) is highly responsive to crizotinib, an oral ATP-competitive selective inhibitor of ALK. However, crizotinib exhibits extremely poor blood–brain barrier penetration; therefore, it is considered to play a limited role in th...

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Main Authors: Kinoshita, Yoshiaki, Koga, Yasutaka, Sakamoto, Atsuhiko, Hidaka, Kouko
Format: Artigo
Jezik:Inglês
Izdano: BMJ Publishing Group 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3794239/
https://ncbi.nlm.nih.gov/pubmed/24022905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bcr-2013-200867
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