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CRISPR RNA-guided activation of endogenous human genes
Catalytically inactive CRISPR-associated 9 nuclease (dCas9) can be directed by short guide RNAs (gRNAs) to repress endogenous genes in bacteria and human cells. Here we show that a dCas9-VP64 transcriptional activation domain fusion protein can be directed by single or multiple gRNAs to increase exp...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3794058/ https://ncbi.nlm.nih.gov/pubmed/23892898 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.2598 |
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