Generation of Interleukin-2 Receptor Gamma Gene Knockout Pigs from Somatic Cells Genetically Modified by Zinc Finger Nuclease-Encoding mRNA

Zinc finger nuclease (ZFN) is a powerful tool for genome editing. ZFN-encoding plasmid DNA expression systems have been recently employed for the generation of gene knockout (KO) pigs, although one major limitation of this technology is the use of potentially harmful genome-integrating plasmid DNAs....

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Hauptverfasser: Watanabe, Masahito, Nakano, Kazuaki, Matsunari, Hitomi, Matsuda, Taisuke, Maehara, Miki, Kanai, Takahiro, Kobayashi, Mirina, Matsumura, Yukina, Sakai, Rieko, Kuramoto, Momoko, Hayashida, Gota, Asano, Yoshinori, Takayanagi, Shuko, Arai, Yoshikazu, Umeyama, Kazuhiro, Nagaya, Masaki, Hanazono, Yutaka, Nagashima, Hiroshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3793986/
https://ncbi.nlm.nih.gov/pubmed/24130776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0076478
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