An Interferon-α-Induced Tethering Mechanism Inhibits HIV-1 and Ebola Virus Particle Release but Is Counteracted by the HIV-1 Vpu Protein

Type 1 interferon (IFN) inhibits the release of HIV-1 virus particles via poorly defined mechanisms. Here, we show that IFNα induces retention of viral particles on the surface of fibroblasts, T cells, or primary lymphocytes infected with HIV-1 lacking the Vpu protein. Retained particles are tethere...

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Hlavní autoři: Neil, Stuart J.D., Sandrin, Virginie, Sundquist, Wesley I., Bieniasz, Paul D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3793644/
https://ncbi.nlm.nih.gov/pubmed/18005734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2007.08.001
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