Hypoxia and Human Genome Stability: Downregulation of BRCA2 Expression in Breast Cancer Cell Lines

Previously, it has been reported that hypoxia causes increased mutagenesis and alteration in DNA repair mechanisms. In 2005, an interesting study showed that hypoxia-induced decreases in BRCA1 expression and the consequent suppression of homologous recombination may lead to genetic instability. Howe...

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Bibliografski detalji
Glavni autori: Fanale, Daniele, Bazan, Viviana, Caruso, Stefano, Castiglia, Marta, Bronte, Giuseppe, Rolfo, Christian, Cicero, Giuseppe, Russo, Antonio
Format: Artigo
Jezik:Inglês
Izdano: Hindawi Publishing Corporation 2013
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3793298/
https://ncbi.nlm.nih.gov/pubmed/24171172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/746858
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