VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment

Lymphangiogenesis, an important initial step in tumor metastasis and transplant sensitization, is mediated by the action of VEGF-C and -D on VEGFR3. In contrast, VEGF-A binds VEGFR1 and VEGFR2 and is an essential hemangiogenic factor. We re-evaluated the potential role of VEGF-A in lymphangiogenesis...

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Main Authors: Cursiefen, Claus, Chen, Lu, Borges, Leonardo P., Jackson, David, Cao, Jingtai, Radziejewski, Czeslaw, D’Amore, Patricia A., Dana, M. Reza, Wiegand, Stanley J., Streilein, J. Wayne
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2004
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC379325/
https://ncbi.nlm.nih.gov/pubmed/15057311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200420465
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