A deletion polymorphism in the Caenorhabditis elegans RIG-I homolog disables viral RNA dicing and antiviral immunity

RNA interference defends against viral infection in plant and animal cells. The nematode Caenorhabditis elegans and its natural pathogen, the positive-strand RNA virus Orsay, have recently emerged as a new animal model of host-virus interaction. Using a genome-wide association study in C. elegans wi...

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Bibliographic Details
Main Authors: Ashe, Alyson, Bélicard, Tony, Le Pen, Jérémie, Sarkies, Peter, Frézal, Lise, Lehrbach, Nicolas J, Félix, Marie-Anne, Miska, Eric A
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2013
Subjects:
Genomics and Evolutionary Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3793227/
https://ncbi.nlm.nih.gov/pubmed/24137537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.00994
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