HIV-1 Vpr Induces the Degradation of ZIP and sZIP, Adaptors of the NuRD Chromatin Remodeling Complex, by Hijacking DCAF1/VprBP

The Vpr protein from type 1 and type 2 Human Immunodeficiency Viruses (HIV-1 and HIV-2) is thought to inactivate several host proteins through the hijacking of the DCAF1 adaptor of the Cul4A ubiquitin ligase. Here, we identified two transcriptional regulators, ZIP and sZIP, as Vpr-binding proteins d...

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Main Authors: Maudet, Claire, Sourisce, Adèle, Dragin, Loïc, Lahouassa, Hichem, Rain, Jean-Christophe, Bouaziz, Serge, Ramirez, Bertha Cécilia, Margottin-Goguet, Florence
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3792905/
https://ncbi.nlm.nih.gov/pubmed/24116224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0077320
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