TGF-β Signalling Is Required for CD4(+) T Cell Homeostasis But Dispensable for Regulatory T Cell Function

TGF-β is widely held to be critical for the maintenance and function of regulatory T (T(reg)) cells and thus peripheral tolerance. This is highlighted by constitutive ablation of TGF-β receptor (TR) during thymic development in mice, which leads to a lethal autoimmune syndrome. Here we describe that...

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Detalhes bibliográficos
Main Authors: Śledzińska, Anna, Hemmers, Saskia, Mair, Florian, Gorka, Oliver, Ruland, Jürgen, Fairbairn, Lynsey, Nissler, Anja, Müller, Werner, Waisman, Ari, Becher, Burkhard, Buch, Thorsten
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3792861/
https://ncbi.nlm.nih.gov/pubmed/24115907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001674
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