Physicochemical characterization and in vitro dissolution studies of solid dispersions of ketoprofen with PVP K30 and d-mannitol

Aim of the present study was to improve the solubility and dissolution rate of poorly water soluble, BCS class-II drug Ketoprofen (KETO) by solid-dispersion approach. Solid dispersions were prepared by using polyvinylpyrrolidone K30 (PVP K30) and d-mannitol in different drugs to carrier ratios. Disp...

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Autors principals: Yadav, Pankajkumar S., Kumar, Vikas, Singh, Udaya Pratap, Bhat, Hans Raj, Mazumder, B.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3792622/
https://ncbi.nlm.nih.gov/pubmed/24109206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsps.2011.12.007
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