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Amination of Heteroaryl Chlorides: Palladium Catalysis or S(N)Ar in Green Solvents?

The reaction of heteroaryl chlorides in the pyrimidine, pyrazine and quinazoline series with amines in water in the presence of KF results in a facile S(N)Ar reaction and N-arylation. The reaction is less satisfactory with pyridines unless an additional electron-withdrawing group is present. The res...

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Bibliografiset tiedot
Päätekijät: Walsh, Katie, Sneddon, Helen F, Moody, Christopher J
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: WILEY-VCH Verlag 2013
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3792620/
https://ncbi.nlm.nih.gov/pubmed/23794470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cssc.201300239
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