Obligate Short-Arm Exchange in De Novo Robertsonian Translocation Formation Influences Placement of Crossovers in Chromosome 21 Nondisjunction

Robertsonian translocations (ROBs) involving chromosome 21 are found in ∼5% of patients with Down syndrome (DS). The most common nonhomologous ROB in DS is rob(14q21q). Aberrant recombination is associated with nondisjunction (NDJ) leading to trisomy 21. Haplotype analysis of 23 patients with DS and...

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Main Authors: Berend, Sue Ann, Page, Scott L., Atkinson, William, McCaskill, Christopher, Lamb, Neil E., Sherman, Stephanie L., Shaffer, Lisa G.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society of Human Genetics 2003
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC379241/
https://ncbi.nlm.nih.gov/pubmed/12506337
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