Obligate Short-Arm Exchange in De Novo Robertsonian Translocation Formation Influences Placement of Crossovers in Chromosome 21 Nondisjunction

Robertsonian translocations (ROBs) involving chromosome 21 are found in ∼5% of patients with Down syndrome (DS). The most common nonhomologous ROB in DS is rob(14q21q). Aberrant recombination is associated with nondisjunction (NDJ) leading to trisomy 21. Haplotype analysis of 23 patients with DS and...

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Detalhes bibliográficos

Publicado no:	Am J Hum Genet
Principais autores:	Berend, Sue Ann, Page, Scott L., Atkinson, William, McCaskill, Christopher, Lamb, Neil E., Sherman, Stephanie L., Shaffer, Lisa G.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2002
Assuntos:	Report
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC379241/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12506337/ https://ncbi.nlm.nih.govhttps://doi.org/10.1086/367547
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