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Vaccination with prion peptide-displaying papillomavirus-like particles induces autoantibodies to normal prion protein that interfere with pathologic prion protein production in infected cells

Prion diseases are fatal neurodegenerative disorders caused by proteinaceous infectious pathogens termed prions (PrP(Sc)). To date, there is no prophylaxis or therapy available for these transmissible encephalopathies. Passive immunization with monclonal antibodies recognizing the normal host-encode...

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Библиографические подробности
Главные авторы: Handisurya, Alessandra, Gilch, Sabine, Winter, Dorian, Shafti-Keramat, Saeed, Maurer, Dieter, Schätzl, Hermann M., Kirnbauer, Reinhard
Формат: Artigo
Язык:Inglês
Опубликовано: 2007
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3792370/
https://ncbi.nlm.nih.gov/pubmed/17313482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2007.05721.x
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