Role of Cysteines in the Stability and DNA-Binding Activity of the Hypochlorite-Specific Transcription Factor HypT

Reactive oxygen species are important components of the immune response. Hypochlorite (HOCl) is produced by neutrophils to kill invading microorganisms. The bactericidal activity of HOCl is due to proteome-wide unfolding and oxidation of proteins at cysteine and methionine residues. Escherichia coli...

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Main Authors: Drazic, Adrian, Tsoutsoulopoulos, Amelie, Peschek, Jirka, Gundlach, Jasmin, Krause, Maike, Bach, Nina C., Gebendorfer, Katharina M., Winter, Jeannette
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3792123/
https://ncbi.nlm.nih.gov/pubmed/24116067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0075683
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