Branched polyethylenimine-grafted-carboxymethyl chitosan copolymer enhances the delivery of pDNA or siRNA in vitro and in vivo

To generate a good carrier for gene transfection, O-carboxymethyl chitosan-graft-branched polyethylenimine (OCMPEI) copolymers were synthesized by increasing the weight percentage of branched polyethylenimine conjugated to the carboxyl groups of O-carboxymethyl chitosan. These spherical polyplexes w...

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Autores principales: Park, Seong-Cheol, Nam, Joung-Pyo, Kim, Young-Min, Kim, Jun-Ho, Nah, Jae-Woon, Jang, Mi-Kyeong
Formato: Artigo
Lenguaje:Inglês
Publicado: Dove Medical Press 2013
Materias:
Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3792010/
https://ncbi.nlm.nih.gov/pubmed/24106426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S50911
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